CHEM 252 - Organic Chemistry II

5 Credit: (3 lecture, 3 lab, 0 clinical) 6 Contact Hours: [CHEM 251 ]

1. Describe the stable nature of aromatic compounds
2. Apply the criteria (two) for aromaticity
3. Examine various heterocyclic compounds for aromaticity
4. Recite the consequences of aromaticity and depict the molecular orbital for aromaticity and antiaromaticity
5. Name various monosubstituted benzenes
6. Describe, using a mechanistic approach (Electrophilic Aromatic Substitution), the following reactions of benzene:
   1. Halogenation
   2. Nitration
   3. Sulfonation
   4. iv. Friedel-Crafts Acylation
   5. v. Friedel-Crafts Alkylation
   6. vi. Alkylation by acylation-reduction
7. Demonstrate coupling reactions
8. Name and write formulas for di- and polysubstituted benzenes
9. Explain how substituents can increase or decrease benzene ring reactivity
10. Describe the effect that substituents have on the pKa of aromatic compounds
11. Describe the synthesis of mons, di, and trisubstituted benzenes
12. Examine the addition-elimination mechanisms for nucleophilic aromatic substitution

Goal 2:  Describe reactions of carbonyl compounds.

1. Describe the structural and physical properties of carbonyl compounds, including carboxylic acids (and their derivatives), aldehydes, and ketones
2. Recite the nomenclature of carbonyl compounds
3. Explain the mechanism for Nucleophilic Acyl Substitution reactions
4. Predict the products of carbonyl compounds and acyl halides, acid anhydrides, esters, amides imides, and nitriles.
5. Describe characteristics of soaps, detergents, and Micelles
6. Describe reactions of aldehydes and ketones
7. Describe reactions of carbonyl compounds with Grignard Reagents, acetylide ions, and hydride ions.
8. Describe reactions of aldehydes and ketones with HCN, amines, water, and alchols.
9. Explain the function of protecting groups in organic reactions
10. Predict the product(s) of the Wittig reaction.
11. Identify the products of Nucleophilic Addition reactions of aldehydes, ketones, and carboxylic acid derivatives.
12. Discuss the acidity of an alpha hydrogen
13. Explain and differentiate between Keto-Enol Tautomers, Enolization, and their reactivity
14. Describe reactions at the α-carbon of aldehydes, ketones, and carboxylic acids
15. Describe mixed aldol addition, Claisen condensation, Malonic ester synthesis, and acetoacetic ester synthesis.

Goal 3:  Investigate oxidation-reduction reactions of organic compounds including amines.

1. Predict the products of the oxidation of alcohols, aldehydes, ketones, diols, amines, alkenes, and alknyes.
2. Recite the nomenclature of amine compounds
3. Generalize how amines act as bases and nucleophiles
4. Describe properties of aromatic amines

Goal 4:  Describe the properties of carbohydrates, amino acids, peptides, and proteins.

1. Recognize bioorganic compounds
2. Classify carbohydrates and recognize the D and L forms
3. Examine various reactions of monosaccharides
4. Distinguish between aldoses and ketoses
5. Identify lengthening chain reactions (Kiliani-Fisher synthesis) and shortening chain reactions (Wohl Degradation reaction)
6. Describe the formation of cyclic hemiacetals
7. Recognize glycosides and their formation
8. Distinguish between reducing and nonreducing sugars
9. Explain the anomeric effect
10. Summarize the classification and nomenclature of amino acids
11. Recognize the acid-base properties of amino acids
12. Differentiate between peptide and disulfide bonds
13. Recognize secondary, tertiary, and quaternary structures of proteins

Goal 5:  Demonstrate techniques involved in the laboratory separation, analysis, synthesis, and purification of organic compounds.

1. Describe the essential features of mass spectroscopy and interpret a mass spectrum
2. Describe the essential features of infrared spectroscopy and interpret an IR spectrum
3. Describe the essential features of visible and UV spectroscopy
4. Review the Beer-Lambert Law
5. Describe the essential features of H NMR spectroscopy and interpret an H NMR spectrum
6. Describe C-13 NMR spectroscopy